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KMID : 1138720200460040025
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Korean Public Health Research
2020 Volume.46 No. 4 p.25 ~ p.39
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The incidence of metabolic syndrome in breast cancer survivors: Systematic review and meta-analysis
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Kwon Hyang-Suk
Yang Young-Ran
Kim Hyun-Kyung
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Abstract
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Purpose: The purpose of this study is to identify the risk of metabolic syndrome in breast cancer survivors through systematic review and meta-analysis.
Methods: We searched articles in the MEDLINE (PubMed), The Cochrane Library, Web of Science and CINAHL published between January 1986 to May 2020. Two researchers independently reviewed and selected articles, based on PRISMA (Preferred Reporting Items of Systematic Reviews and Meta-Analyses) and we calculated with the incidence ratio of metabolic syndrome (OR, Odds Ratio), and tested for homogeneity and publication bias using the Compressive Meta-Analysis version 3.3.070 program.
Result: Out of 756 articles meeting the initial criteria, 8 cases-control studies, which involved 15,479 participants (1,463 cases and 14,016 controls) were included in the final analysis. In a sum of analysis, 5,059 developed metabolic syndrome, representing a incidence rate of 32.68%. Compared with the healthy control groups, the cancer survivors were at an increased risk of metabolic syndrome, in the random-effects meta-analysis of all 8 cases-control studies (OR = 1.628; 95% CI = 1.087-2.437; p = 0.018; I2 = 81.91%). In the subgroup meta-analysis, four studies of postmenopausal breast cancer survivors and three of the types of metabolic syndrome definitions using the NCEP-ATP III criterion were significantly associated with the risk of metabolic syndrome.
Conclusion: Higher incidence of metabolic syndrome among breast cancer survivors found compared to healthy control group. Recognizing the risk of metabolic syndrome in breast cancer survivors, active intervention should be made for the prevention of metabolic syndrome in breast cancer survivors. This study informs the development of an evidence-based integrated program to prevent metabolic syndrome, further cardiovascular disease, in breast cancer survivors.
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KEYWORD
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Metabolic syndrome, Breast neoplasms, Cancer survivors, Incidence, Meta-analysis
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